One man’s view of Hodgkin's disease |
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Authors: | Nicholas J. Vianna |
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Affiliation: | (1) Occupational Health and Chronic Disease Research, New York State Department of Health, Tower Building, Empire State Plaza, 12237 Albany, N.Y., USA |
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Abstract: | Summary Despite its many heterogeneous features, Hodgkin's disease is most likely a single neoplastic disorder in which some common viral agent of low virulence and infectivity might be of etiologic importance. Family factors such as birth order influence age of initial exposure, a major determinant of the outcome of infection—clinical disease versus immunity. The various epidemiologic patterns for this lymphoma observed internationally are probably a reflection of different levels of natural immunity acquired in childhood. Host factors might be responsible for the male excess of Hodgkin's disease, particularly in childhood. |
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Keywords: | Epidemiology Family factors Hodgkin’ s disease Immunity Neoplasias |
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