| 环孢素A脂质体制备及其体外释药方法学考察 |
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| 引用本文： | 许洁,杨志强,潘萍,张学农,吴函珊.环孢素A脂质体制备及其体外释药方法学考察[J].抗感染药学,2008,5(4):222-227. |
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| 作者姓名： | 许洁 杨志强 潘萍 张学农 吴函珊 |
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| 作者单位： | 苏州大学药学院,江苏,苏州,215123 |
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| 基金项目： | 江苏省科技厅社会发展项目资助，江苏省高新技术产业发展项目资助，江苏省卫生厅招标课题，苏州大学医学发展基金资助 |
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| 摘 要： | 目的：考察环孢素A（cyclosporinA，csA）脂质体的制备方法、理化性质及其体外释放行为。方法：比较薄膜分散法、逆向蒸发法、乙醇注入法、乙醚注入法所得的环孢素A脂质体（CsA—Lip），并以包封率和载药量为综合指标，正交设计优化CsA—Lip处方工艺；分别采用动态透析法和超速离心法研究CsA—Lip的体外释放行为。结果：乙醇注入法制备CsA—Lip的平均粒径为（80．41±3．12）nm，包封率为（87．09±0．03）％，载药量为（4．98±0.45）％，24h释放44％。结论：经优化制备的CsA脂质体具有较高的包封率和载药量，并具有缓释作用。
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| 关 键 词： | 环孢素A 脂质体 体外释放 超速离心 |
Studies on Preparation and Releasing of Cyclosporin A Liposome in Vitro |
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| XU Jie,YANG Zhi-qiang,PAN Ping,ZHANG Xue-nong,WU Han-shan.Studies on Preparation and Releasing of Cyclosporin A Liposome in Vitro[J].Anti-infection Pharmacy,2008,5(4):222-227. |
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| Authors: | XU Jie YANG Zhi-qiang PAN Ping ZHANG Xue-nong WU Han-shan |
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| Institution: | XU Jie~(1*2) YANG Zhi-qiang~1 PAN Ping~1 ZHANG Xue-nong~(1*3) WU Han-shan~2 1 School of Pharmacy,Soochow University,Suzhou Jiangsu 215123,China,2 07 Graduate of Pharmacy,School of Pharmacy |
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| Abstract: | Objective:To study the preparation methods of Cyclosporin A liposomc(CsA-Lip) and its characteristics in vitro.Methods:Selecting a proper method from thin film vesicle,reverse-phase evaporation,ethanol-injection and ether- injection technique.The optimized formulation was screened by orthogonal experimental design with entrapment efficiency and loading quality of CsA-Lip as general indexes.The CsA release from drug-loaded liposome was investigated with bag filter and ultracentrifugation in vitro.Results:The... |
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| Keywords: | cyclosporin A liposome releasing in vitro ultracentrifugation |
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