CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects |
| |
| Authors: | Buerger K Teipel S J Zinkowski R Blennow K Arai H Engel R Hofmann-Kiefer K McCulloch C Ptok U Heun R Andreasen N DeBernardis J Kerkman D Moeller H- J Davies P Hampel H |
| |
| Institution: | Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. katharina.buerger@psy.med.uni-muenchen.de |
| |
| Abstract: | In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
