An efficient synthesis of 3-(E)-hydroxypropenyl cephem derivatives, key intermediates for 3-(E)-ammoniopropenylcephalosporin antibiotics |
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| Authors: | Yong Sup Lee Jae Yeol Lee Jin-Hyun Jeong Hokoon Park |
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| Affiliation: | (1) Division of Applied Science, Korea Institute of Science & Technology, Cheongryang, P.O. Box 131, 130-650 Seoul, Korea |
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| Abstract: | An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylcephem derivatives, key intermediates for the synthesis of 3-(E)-propenylcephalosporins was achievedvia Stille coupling reaction of 3-trifloxycephem with 3-(E)-tributylstannylallylic alcohol. |
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| Keywords: | Ammoniopropenyl 3-(E)-Propenylcephem Cephalosporins Antibacterial Stille coupling |
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