无抽搐电休克对精神分裂症患者认知功能及短时记忆损伤的影响

<正>精神分裂症(SP)是一种较常见的精神疾病,存在一定程度的认知功能损害[1]。目前临床治疗SP需长期接受药物治疗,但不良反应较多[2]。无抽搐电休克治疗(MECT)是一种物理治疗方法,通过给予患者短暂适量的电流刺激使患者丧失意识,控制精神分裂症状。有研究认为,MECT可造成患者治疗后短时记忆功能损害[3]。本研究应用无抽搐电休克治疗SP患者,观察其临床疗效,并评估对短时记忆损伤及认知功能的影响。1临床资料1.1一般资料选择浙江省义乌市精神卫生中心

The influence on short-term memory impairment and cognitive function of non-convulsive electroconvulsive treatment for schizophreniaMei Shifeng, Yiwu mental health center, psychiatry 322000

Objective Patients with schizophrenia (SP) treated with non-convulsive electroconvulsive shock(MECT),to observe its clinical curative effect and evaluate the impact on short-term memory impairment and cognitive function, and provide basis for clinical treatment of SP patients. Methods 90 SP patients in hospital were selected from January in 2016 to July in 2017,they were divided into the control group and study group according to the admission single and double numbers randomly,45 patients in each group.The control group received routine treatment,and the study group was performed electroconvulsive therapy without convulsions on the basis of control group. The positive and negative symptom scores (PANSS), connection test A (TMT-A) and B (TMT-B) were used to assess the improvement of symptoms and cognitive function before treatment, 3 weeks and 6 weeks after treatment. Wechsler Memory Scale (WMS) was used to evaluate the short-term memory function of patients with memory quotient (MQ) Results PANSS positive symptoms, negative symptoms, total scores and TMT-A and TMT-B of study group after treatment 3 and 6 weeks were (11.51±0.94) points, (11.41±0.65) points, (39.23±2.30) points, 8.39±0.97) points, (8.92±0.69) points, (31.46±2.17) points, (62.43±3.04)s, (95.31±4.86)s, (54.26±2.85)s, (89.46±4.72)s respectively, all lower than the control group (13.27±1.06) points, (12.49±0.78) points, (42.72±2.26) points, (9.98±0.91) points, (10.05±0.72) points, (35.24±2.55) points, (65.62±3.21)s, (98.69 ± 5.04) s, (57.39 ± 2.86) s, (91.44 ± 5.12) s, the difference was statistically significant (P <0.05). After treatment for 3 weeks and 6 weeks,MQ results of the study group were (69.23±2.30) points and (70.46±2.17) points, which were all lower than before treatment, however MQ results after treatment six weeks higher than after treatment three weeks,the difference was statistically significant(P<0.05).Conclusion Application MECT for the treatment of patients with SP can effectively improve the patient"s psychiatric symptoms, cognitive function. The patient"s short-term memory has some damage, while it can be restored quickly.