口腔幽门螺杆菌感染及其检测技术的现状和展望

幽门螺杆菌（Hp）是一种具有高感染率的致病菌，常导致终身感染。Hp在口腔中寄居可能是造成消化道疾病反复发作的一个重要原因，同时也会影响胃Hp根除治疗的疗效。由于口腔的微生态环境与胃内不同，细菌培养、快速尿素酶试验（RUT）、聚合酶链反应（PCR）等胃内Hp的检测方法在检测口腔Hp感染时结果存在很大差异。唾液Hp尿素酶抗原检测法（HPS）是一种免疫显色的图解化验法。通过唾液Hp培养和（或）HPS检测可探明口腔Hp的存在，从而可以通过制订胃、口同步治疗的全新方案，提高Hp根除率。此文就口腔Hp感染及其与胃Hp感染的相关性，口腔Hp检测与培养的新技术等最新进展作了综述。

Progress on oral Helicobacter pylori infection and its diagnostic techniques

Helicobacter priori （Hp） is of high prevalence and can cause lifelong infection. Hp can parasite in oral cavity, which may be not only an important cause of recuent gastrointestinal diseases, but also affect Hp eradication in stomach. Bacterial culture, rapid urease test （ RUT ） and polymerase chain reaction （PCR） have been widely used in diagnosis of gastrointestinal Hp infections. While due to the difference of microbial environments in oral cavity and in stomach, there exit big disparities when they are used to detect Hp in oral cavity. Saliva Hp urease antigen detection method （HPS） is a graphic immune chromogenic assay. Hp salivary culture with HPS test can help to confirm the existence of Hp in oral cavity, so as to improve Hp eradication rate through concurrent treatment of gastrointestinal and oral Hp infections. The status of oral Hp infection, its correlation with gastric Hp infection, and new techniques of oral Hp detection and culture are reviewed in this article.