早发冠心病急性心肌梗死患者的临床分析

目的：分析早发冠心病（PCAD）急性心肌梗死（AMI）患者的传统危险因素及冠状动脉的病变特点。方法：对98例PCAD—AMI患者（PCAD组）、114例晚发冠心病（LCAD）AMI患者（LCAD组）及82例非冠心病者（非冠组）的传统危险因素及冠状动脉的病变特点进行分析。结果：危险因素分析显示，PCAD组阳性家族史的比率显著高于LCAD组（P〈0．01）；PCAD、LCAD两组与非冠组比较，各项危险因素均偏高，差异有统计学意义（P〈0．01或P〈0．05）。冠状动脉造影结果显示，PCAD组单支病变比率比LCAD组高（P〈0．01）。PCAD组的单支闭塞率与LCAD组相近，未见双支闭塞者。PCAD组的每例单个支架置入比率显著高于LCAD组（P〈0．01）。结论：PCAD—AMI患者的发病与传统危险因素密切相关；PCAD组的冠状动脉病变轻于LCAD组；经皮冠脉介入术是PCAD—AMI患者十分有效的治疗方法之一。

Clinical analysis of premature coronary artery disease in patients with acute myocardial infarction

Objective： To analyze the traditional risk factors and coronary lesion characteristics of patients with premature coronary artery disease （PCAD） with acute myocardial infarction （AMI）. Methods： The traditional risk factors and coronary lesion characteristics of angiography and interventional treatment of 98 PCAD-AMI patients （PCAD group）, 114 late-onset coronary artery disease （LCAD） AMI patients （LCAD group） and 82 non-coronary artery disease patients （non-CAD group） were analyzed. Results： Risk factor analysis showed that the ratio of positive family history of PCAD group was significantly higher than that of LCAD group （P〈0.01）; the risk factors of PCAD group and LCAD group were higher than those of non- CAD group （P〈0.01 or P〈0.05）. Coronary angiography result showed that the incidence Of single-vessel disease in PCAD group was higher than that in LCAD group （P〈0.01）. The single vessel occlusion rate of PCAD group was similar to that of LCAD group and there was no double-vessel occlusion. The single stent per patient ratio of PCAD group was significantly higher than that of LCAD group （P〈0.01）. Conclusion： PCAD-AMI is closely related to the traditional risk factors. The coronary lesions of PCAD group are lighter than those of LCAD group. Percutaneous coronary intervention is a very effective treatment for patients with PCAD-AMI.