胸腺瘤患者预后因素分析

目的 探讨影响胸腺瘤患者术后远期生存率的相关因素。方法 回顾性分析我科1973—2000年间手术治疗的69例胸腺瘤，应用Kaplan—Meier法和Cox比例风险模型对可能影响胸腺瘤术后远期生存率的因素进行单因素和多因素分析。结果 全组患者5年、10年、15年生存率分别为83．3％、67．4％、41．9％。单因素分析显示年龄、Masaoka分期、WHO组织学分类、肿瘤切除范围、Rosai／Levine分类对胸腺瘤患者术后长期生存率有显著影响(P＜0．01)，但经多因素分析表明仅Masaoka分期(P＜0．01)、肿瘤切除范围(P＜0．05)、年龄(P＜0．05)是独立的预后因素。结论 对胸腺瘤应积极进行手术治疗，即使姑息性切除亦有助于提高远期生存。

Prognostic factors of patients with thymoma

Objective To explore the prognostic factors affecting the long-term survival of patients with thymoma. Methods Sixty-nine patients with thymoma surgically treated in our department from 1973 to 2000 were studied retrospectively. The possible prognostic factors were analyzed by univariate analysis and multivariate analysis with Kaplan-Meier method and Cox proportional hazard model, respectively. Results Overall patients survival rates were 83.3%,67.4%,41.9% at 5, 10, 15 years, respectively. The significant prognostic factors demonstrated by univariate analysis included age, Masaoka staging, WHO histologic classification, completeness of resection, and Rosai/Levine classification ( P <0 01). According to multivariate analysis, the independent prognostic factors included Masaoka staging( P <0.01), completeness of resection( P <0.05), age of the patients ( P <0.05). Conclusion Complete surgical resection of thymomas helps increase the long-term survival rate.