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Vascular endothelial growth factor mRNA expression can be a marker for response to antiviral treatment of HCV |
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| Authors: | Ahmed M El-Gohary Fadia M Attia Abeer Rabee Galal Eldin Adel A Hassen Nader A Nemer Fawzy A Kalil |
| Institution: | 1. Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt 2. Medical Microbiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt 3. Infectious diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt 4. Internal Medicine Departments, Faculty of Medicine, Suez Canal University, Ismailia, Egypt |
| Abstract: | Angiogenesis has a significant pathogenic role in liver damage-associated hepatitis C virus infection. We evaluated whether chronic hepatitis C (CHC) is associated with elevated levels of angiogenesis marker (vascular endothelial growth factor) and whether it is modulated by therapy. Vascular endothelial growth factor (VEGF) mRNA was determined in the 36 CHC patients included in this study before therapy and 12 weeks after receiving antiviral combination therapy, pegylated interferon alpha-2b plus ribavirin, compared to 20 healthy controls. CHC patients showed elevated baseline VEGF level before and during treatment, but it was decreased in responder group, indicating a shift toward an “anti-angiogenic” process in CHC patients. In conclusion, this suggests that VEGF mRNA level could be useful as non-invasive, base markers of response to therapy. |
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