鳖甲煎丸对糖尿病合并动脉粥样硬化大鼠血脂、血管内皮功能以及基质金属蛋白酶9的影响

目的：观察鳖甲煎丸对糖尿病合并动脉粥样硬化大鼠血脂、内皮素（ET）、一氧化氮（NO）、基质金属蛋白酶9（MMP-9）的影响。方法：将造模成功后雄性SD 大鼠随机分为空白组、模型组、鳖甲煎丸低剂量组、鳖甲煎丸高剂量组、血脂康组。灌胃8 周后，观察不同组别大鼠血脂、血清ET-1、血清NO、MMP-9 的变化。结果：与空白组比较，模型组血清NO 水平显著降低（P<0.05），ET-1 水平明显升高（P<0.05）；与模型组比较，鳖甲煎丸高、低剂量组、血脂康均能显著降低血清ET-1 含量（P<0.05 或P<0.01）、 升高NO 含量（P<0.05 或P<0.01）、MMP-9 表达明显下降（P<0.05）。结论：鳖甲煎丸可能通过调脂、保护血管内皮细胞、稳定斑块等作用起到抗动脉粥样硬化的作用。

Effect of Bie-Jia-Jian Pill on Blood Lipids, Endothelial Function and MMP-9 of Diabetes Rat Model with Atherosclerosis

This article was aimed to observe the preventive effect of diabetes with atherosclerosis (AS) treated with Bie-Jia-Jian Pill (BJJP) on level of blood lipids, endothelin (ET), nitric oxide (NO), and matrix metalloproteinase-9 (MMP-9). Male SD rats were randomly divided into 5 groups, which were the blank group, model group, low-dose BJJP group, high-dose BJJP group and Xue-zhi-kang (XZK) group, to observe changes on the level of blood lipids, ET-1, NO and MMP-9 within 5 groups after 8-week administration. The results showed that compared with the blank group, the level of the content of NO in the model group was significantly decreased (P < 0.05), the level of ET-1 was significantly increased (P < 0.05). Compared with the model group, the high-dose and low-dose BJJP group as well as XZK group can significantly decrease the level of ET-1 (P < 0.05, or P < 0.01), increase content of NO (P < 0.05, or P < 0.01), and decrease the expression of MMP-9 (P < 0.05). It was concluded that the BJJP can regulate blood lipids, protect endothelial cell of blood vessels, stabilize plaques for the anti-AS effect.