Glutathione S-transferase genotypes and numerical chromosomal aberrations in myeloid neoplasms

The aim of the present study was to detect the frequency of monosomy 7 and trisomy 8 in myeloid disorders (acute myeloblastic leukemia (AML), myelodysplastic syndrome (MDS)), their association with GSTT1 and GSTM1 null genotypes, and their prognostic impact. The study included 50 patients with AML and MDS; monosomy 7 and trisomy 8 detection was done by interphase fluorescence in situ hybridization, and glutathione S-transferase (GST) genotyping was done by multiplex PCR. Monosomy 7 was present in 13–30 % of AML and MDS, respectively. A statistically significant relation was found between monosomy 7 and remission failure. Trisomy 8 was found in 10–15 % of AML and MDS. No significant association was found between response to treatment and trisomy 8. There was significant correlation between GSTT1 null/GSTM1 null genotype and poor response to treatment (p < 0.005). There was positive correlation between complete remission and both wild GST genotypes. In the whole patient group, a statistically significant association was found between GSTT null genotypes and monosomy 7 (p = 0.003). No significant association was found between trisomy 8 and specific GST genotypic polymorphism.