Mechanism of inhibition of small intestinal motility by restraint stress differs from that with norepinephrine treatment in rats |
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Authors: | Tsukada Fumitake Sawamura Kuniko Kohno Hiroyuki Ohkubo Yasuhito |
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Affiliation: | Department of Radiopharmacy, Tohoku Pharmaceutical University, Sendai, Japan. |
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Abstract: | We have previously reported that restraint stress inhibits small intestinal motility in rats, and that the adrenergic beta3-antagonist SR59230A administration recovered the inhibition. In the present study, we compared the effects of restraint stress and norepinephrine on small intestinal motility using alpha- and beta-adrenergic antagonists. SR59230A did not recover the norepinephrine-induced inhibition of small intestinal motility. The norepinephrine-induced inhibition of small intestinal motility was recovered after administration of the alpha2-antagonist yohimbine, but not by alpha1-, beta1-, and beta2-antagonists. Considering these results, it is reasonable to assume that the mechanisms of inhibition of small intestinal motility due to restraint stress and norepinephrine treatment are different. |
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