| 中介素在低氧性肺动脉高压大鼠中的变化和意义 |
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| 引用本文： | 霍秀青,于忠和,王萍.中介素在低氧性肺动脉高压大鼠中的变化和意义[J].中国基层医药,2002,16(1):1015-1016. |
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| 作者姓名： | 霍秀青 于忠和 王萍 |
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| 作者单位： | 第三军医大学硕士研究生,北京解放军306医院呼吸科,100101;北京军区总医院;北京解放军306医院; |
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| 摘 要： | 目的 观察比较中介素在低氧性肺动脉高压大鼠血浆和支气管肺泡灌洗液含量的变化.方法 雄性Wistar大鼠被随机分为4组,对照组、低氧1周组、2周组、3周组.利用放免分析法测定大鼠血浆和支气管肺泡灌洗液的含量.结果 低氧组大鼠血浆和支气管肺泡灌洗液中介素含量明显高于对照组.同时支气管肺泡灌洗液和血浆的变化趋势一致.结论 中介素血浆和支气管肺泡灌洗液含量增高,提示机体可能对缺氧性肺动脉高压起到一定的缓冲和保护作用.
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| 关 键 词： | 中介素 低氧 肺动脉高压 |
Variety and significance of Intermedin on hypoxic pulmonary arterial hypertension in rats |
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| HUO Xiu-qing,YU Zhong-he,WANG Ping.Variety and significance of Intermedin on hypoxic pulmonary arterial hypertension in rats[J].Chinese Journal of Primary Medicine and Pharmacy,2002,16(1):1015-1016. |
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| Authors: | HUO Xiu-qing YU Zhong-he WANG Ping |
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| Abstract: | Objective To observe and compare the changes of Intermedin's contents in plasma and bron-choalveolar lavage fluid (BALF) in rats with hypoxic pulmonary hypertension. Methods male Wistar rats were ran-domly divided into control group and 1,2 and 3 weeks hypoxia group. Intermedin's contents in plasma and bronchoal-veolar lavage fluid were measured by radioimmunoassay. Results Intermedin's contents in plasma and bronchoalveo-lar lavage fluid were markedly increaseded compared with control group. Meanwhile transformational trend is consist-ent between plasma and bronchoalveolar lavage. Conclusions Intermedin's contents in plasma and bronchoalveolar lavage increase ,which shows that there is protection and moderation to hypoxic pulmonary hypertension. |
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| Keywords: | Intermedinhypoxiapulmonary hypertension |
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