芪龙胶囊对急性应激血瘀大鼠血液流变学的影响

目的 :研究芪龙胶囊对急性应激血瘀大鼠血液流变学的改善作用。方法 :急性应激血瘀大鼠模型采用在两次皮下注射肾上腺素 1mg·kg^-1之间将大鼠置于冰水中 5mim的方法建立。利用此模型观察芪龙胶囊对模型大鼠全血黏度、全血还原黏度、血浆黏度、红细胞压积、红细胞变形性、红细胞聚集性等血液流变学指标的作用。结果 :芪龙胶囊 0.6 ,0.3,0.15g·kg^-1均能明显降低高、中、低切变率下全血黏度 ,降低中、低切变率下全血还原黏度和红细胞压积 ,降低红细胞聚集性 ,并能够显著升高红细胞变形性 (与模型组比较P <0.05 ,P <0.01)。芪龙胶囊 0.6 ,0.3g·kg^-1还可降低模型大鼠血浆黏度 (P <0.05 ,P <0.0 1)。结论 :芪龙胶囊可明显改善急性应激血瘀大鼠多项血液流变学指标。

Effect of Qilong capsule on hemoreology in acute stress blood stasis rats

Objective:To study the influence of Qilong capsule(QLC) on the hemoreology in acute stress blood stasis model rats. Method:The model of acute stress blood stasis rats were induced by putting the rats into ice water between hyodermic epinephrine twice of 1 mg·kg ^-1 . With the models, the effect of QLC on hemoreology such as whole blood viscosity, whole blood reduction viscosity, plasma viscosity, haematocrit (Hct), erythrocyte deformation and erythrocyte aggregation were observed. Result:QLC 0.6,0.3,0.15 g·kg ^-1 could significantly reduce the increase of whole blood viscosity at high middle low shear rate,reduce the whole blood reduction viscosity at middle low shear rate,reduce Hct and erythrocyte aggregation, and increase the erythrocyte deformation in acute stress blood stasis rats ( P <0.05, P <0.01, compared with vehicle). QLC 0.6,0.3 g·kg ^-1 could also reduce plasma viscosity ( P <0.05, P <0.01, compared with vehicle). Conclusion:QLC can significantly improve some indexes of hemoreology in acute stress blood stasis rats.