Antigenic and nucleotide characterization of a herpesvirus isolated from Pacific harbor seals (Phoca vitulina richardsii) |
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| Authors: | D. P. King R. Parselles F. M. D. Gulland J.-M. Lapointe L. J. Lowenstine D. A. Ferrick J. L. Stott |
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| Affiliation: | (1) The Marine Mammal Center, Marin Headlands, GGNRA, Sausalito, California, U.S.A., US;(2) The Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, U.S.A., US |
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| Abstract: | Summary. This report describes the antigenic and nucleotide characterization of a herpes-like virus that has been isolated from the adrenal tissues of neonatal Pacific harbor seals. Infection with this virus has been previously implicated as a major cause of death of animals undergoing rehabilitation. Comparison and phylogenetic analysis of sequenced fragments of the DNA polymerase, glycoprotein B and glycoprotein D genes, and immunofluorescence assay using herpesvirus-specific monoclonal antibodies, demonstrated close similarity of the Pacific harbor seal herpesvirus to European isolates of phocid herpesvirus-1 (PHV-1) and other α-herpesviruses affecting terrestrial carnivores. Received June 22, 1997 Accepted May 16, 1998 |
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