| 实验性失血性休克时血小板功能的变化 |
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| 引用本文： | 胡森,陆熙昶,胡德耀,范成国,刁友芳,侯淦泉.实验性失血性休克时血小板功能的变化[J].第三军医大学学报,1987(4). |
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| 作者姓名： | 胡森 陆熙昶 胡德耀 范成国 刁友芳 侯淦泉 |
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| 作者单位： | 第三军医大学野战外科研究所，第三军医大学野战外科研究所，第三军医大学野战外科研究所，第三军医大学野战外科研究所，第三军医大学野战外科研究所，第三军医大学野战外科研究所 北京解放军304医院创伤外科中心研究室 |
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| 摘 要： | 本实验从粘附、聚集和释放三方面系统观察了家免失血性休克早期血小板功能的变化、结果表明:休克早期血小板功能显著增强。粘附率、聚集率、血5-羟色胺(5-HT)和血栓素B_2(TXB_2)水平显著升高。随休克时间延长,粘附和聚集逐渐抑制,而5-HT和TXB_2水平进行性升高、提示血小板释放的5-HT和TXA_2是参与失血性休克发展的重要体液因素。
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| 关 键 词： | 失血性休克 兔 血小板功能 5-羟色胺 血栓素 |
Platelet Function Changes in Experimental Hemorrhagic Shock |
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| Hu Sen,.Platelet Function Changes in Experimental Hemorrhagic Shock[J].Acta Academiae Medicinae Militaris Tertiae,1987(4). |
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| Authors: | Hu Sen |
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| Abstract: | The effects of hemorrhagic shock on the platelet functions in non-heparinized rabbits were studied. It was found that the platelet adhesiveness and aggregation and the pasma level of serum serotonin and throraboxane B2 significantly increased in the early period of hemorrhagic shock. Thereafter, as the shock was progressing, the platelet adhesiveness and aggregation were gradually inhibited while plasma level of serotonin and thromboxane B2 increased further and reached the peak in the 3rd hour after the onset of shock.The results indicated that the release of vasoactive substances such as serotonin and thromboxane after the activation of platelets seems to play a more important role than platelet adhesion and aggregation in the pathogenesis of hemorrhagic shock. |
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| Keywords: | Hemorrhagic shock Platelet functions Thromboxane Serotonin Rabbit |
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