Combined effects of carbon monoxide and ethanol on the activities of leucine aminopeptidase and glutamic-pyruvic transaminase in the plasma of rats

An investigation was undertaken to determine the influence of single doses of carbon monoxide plus single doses of ethanol, repeated simultaneous doses of carbon monoxide plus ethanol, and repeated dosage of carbon monoxide (ethanol) plus single doses of ethanol (carbon monoxide) on the activities of leucine amino-peptidase and glutamic-pyruvic transaminase in the plasma of rats. Combinations of carbon monoxide and ethanol were found to produce additive effects with respect to the increase of indicator enzymes if at least 50 % of the hemoglobin was saturated with carbon monoxide and if one of the noxious agents was administered in large doses.This paper is dedicated to Professor Dr. Konrad Pohle on the occasion of his 75th birthday.