Assessing health-related quality of life pre[ndash ] and post[ndash ]liver transplantation: A prospective multicenter study |
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| Institution: | 1. RTI International, Research Triangle Park, North Carolina;2. Office of the Assistant Secretary for Planning and Evaluation, USDHHS, Washington DC;1. Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;2. Division of Surgery, Head and Neck, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom;3. Department of Hepatobiliary Surgery, Hampshire Hospitals Foundation Trust, Basingstoke, Hampshire, United Kingdom;1. Department of Clinical Oncology, John Paul II Specialistic Hospital, Krakow, Poland;2. Department of Gynaecological Care, Jagiellonian University Medical College, Krakow, Poland;3. Faculty of Medicine and Surgery, University of Cagliari, Monserrato, Italy;4. Department of Gerontology, Geriatrics and Social Work, Faulty of Education, Ignatianum Academy, Krakow, Poland;5. Department of Medical Education, Jagiellonian University Medical College, Krakow, Poland;6. Faculty of Military Medicine with the Division of Physiotherapy, Lodz Medical University, Lodz, Poland;7. Department of Surgery, Saint Raphael Hospital, Krakow, Poland;8. Quality of Life Department, European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium;9. Health Outcomes Research Unit, Department of Gerontology, Geriatrics, and Social Work, Faculty of Education, Ignatianum Academy, Krakow, Poland;1. Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, NY USA;2. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY USA;3. Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia-Presbyterian Hospital, New York, NY USA;4. Division of Cardiothoracic Surgery, Department of Surgery, Columbia-Presbyterian Hospital, New York, NY USA;5. Department of Rehabilitation Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY 10467, USA;1. Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA;2. Department of Surgery, University of California, San Francisco, San Francisco, CA |
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| Abstract: | We report on a prospective multicenter study to assess pretransplantation and posttransplantation health-related quality of life (HRQL) of liver transplant recipients. HRQL was assessed at several timepoints using a self-completion questionnaire consisting of the EuroQol instrument (EQ-5D) and the 36-Item Short-Form Health Survey (SF-36) health status profile measure. All individuals selected to receive treatment as part of the UK NHS liver transplantation program at each of six liver transplantation centers in England and Wales during a 2-year period (n = 542) were eligible to be included on the study. An overall response rate of 84% (455 responses) was achieved. A paired comparison of HRQL at listing and 3 months posttransplantation showed statistically significant improvements (P lt ] .05) in all dimensions of the SF-36 (with the exception of Bodily Pain P = .686]) and the EQ-5D tariff and visual analogue scale (VAS) scores. An analysis of posttransplantation HRQL over time for patients who survived until the end of the study (24 months posttransplantation) showed a statistically significant improvement (P lt ] .05) for all dimensions of the SF-36 (apart from Mental Health P = .245] and Rolendash ]Emotional dimensions P = .265]) and the EQ-5D VAS and tariff scores. Adjusting for patients who died posttransplantation reduced mean EQ-5D tariff scores substantially, and the change over time in EQ-5D tariff scores was no longer statistically significant (P = .55). Results of regression analysis conducted to assess the importance of patient characteristics and center size on EQ-5D tariff and VAS scores generated posttransplantation indicated there was variation in scores according to patient age and center size. (Liver Transpl 2002;8:263-270.) |
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