Hyperhomocysteinemia in ischemic stroke |
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| Affiliation: | 1. Division of Hematology/Medical Oncology, Department of Medicine, Oregon Health Sciences University, Portland, OR, USA;2. Division of Laboratory Medicine, Department of Pathology, Oregon Health Sciences University, Portland, OR. USA;3. Department of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia 750001, China;4. Institute of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750001, China;5. Heart Centre, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750001, China |
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| Abstract: | In the past decade, elevated levels of plasma homocysteine have emerged as a potential risk factor for vascular disease. Homocysteine is central in the metabolism of multiple vitamins, including cobalamin and folic acid. There are many reasons for elevated homocysteine levels, but folate deficiency is the most common, even in developed countries. Prospective studies correlating risk of heart disease and homocysteine have provided conflicting data. Data are stronger for the risk of cerebrovascular disease being related to high homocysteine concentrations. Therapy for most patients involves vitamin replacement. Early trial data indicate that lowering of homocysteine may reduce vascular complications. |
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