健脾生血颗粒治疗气血两虚型癌因性疲乏的临床疗效研究

目的：探讨健脾生血颗粒治疗气血两虚型癌因性疲乏的临床疗效。方法：选取2021年9月至2021年12月武汉大学人民医院中医科门诊收治的气血两虚型癌因性疲乏患者64例作为研究对象，采用随机数字表法分为观察组和对照组，每组32例。对照组进行非药物治疗(体育活动、心理及营养咨询、睡眠指导等),观察组在对照组的基础上口服健脾生血颗粒，2组连续治疗30 d。观察2组患者治疗前后Piper疲乏量表(PFS)评分、卡诺夫斯凯计分(KPS)评分、匹兹堡睡眠质量指数(PSQI)量表评分、中医证候评分及疗效评价、血常规检测指标及不良反应。结果：1)研究过程中，共有5例患者脱落，最终有59例患者完成治疗。2)治疗后，2组患者PFS评分均较治疗前下降(均P<0.05),且观察组评分低于对照组(P<0.05)。3)治疗后，2组患者KPS评分均较治疗前增加(均P<0.05),且观察组评分高于对照组(P<0.05)。4)治疗后，2组患者PSQI评分均较治疗前下降(均P<0.05),且观察组评分低于对照组(P<0.05)。5)治疗后，2组患者中医证候评分均较治疗前下降(均P<0...

Clinical Observation on Jianpi Shengxue Granules in the Treatment of Cancer-related Fatigue of Patients with Syndrome of Both Qi and Blood Deficiency

To observe the clinical effect of Jianpi Shengxue granule in the treatment of cancer-related fatigue of patients with the syndrome of both qi and blood deficiency.Methods:Sixty-four patients with cancer-related fatigue(syndrome of both qi and blood deficiency) treated in the Department of Traditional Chinese Medicine,Renmin Hospital of Wuhan University from September to December in 2021 were randomized into 2 groups,with 32 patients in each group.The control group received non-medicine therapy(exercise,psychological and nutritional counseling,and guidance for sleep).The observation group received Jianpi Shengxue Granules in addition to the therapy of the control group.The treatment lasted for 30 days.The Piper Fatigue Scale(PFS) scores,Karnofsky Performance Scale(KPS) scores,Pittsburgh Sleep Quality Index(PSQI) scores,the scores and efficacy for TCM syndromes,blood routine indicators,and adverse reactions in the two groups were observed before and after treatment.Results:1) Five patients dropped out during the treatment,and 59 patients completed the whole course of treatment.2) The PFS score after treatment decreased compared with that before treatment(P<0.05),and it was lower in the observation group than in the control group(P<0.05).3) The KPS score after treatment increased compared with that before treatment(P<0.05),and it was higher in the observation group than in the control group(P<0.05).4) The PSQI score after treatment decreased compared with that before treatment(P<0.05),and it was lower in the observation group than in the control group(P<0.05).5) The TCM syndrome scores after treatment decreased compared with those before treatment(P<0.05),and they were lower in the observation group than in the control group(P<0.05).The observation group had higher effective rate on TCM syndromes than the control group(P<0.05).6) The blood routine indicators in the control group showed no significant changes before and after treatment(P>0.05),while those in the observation group elevated after treatment(P<0.05).7) During the treatment period,no adverse reactions associated with Jianpi Shengxue Granules occurred.Conclusion:Jianpi Shengxue Granules has therapeutic effect on cancer-related fatigue in the patients with syndrome of both qi and blood deficiency.