血清三叶因子3水平联合尿素、肌酐、胱抑素C及肾小球滤过率估算值在糖尿病肾病诊断中的临床价值探讨

目的 探讨血清三叶因子3(TFF3)联合尿素(UREA)、肌酐(Cr)、胱抑素C(Cys-C)及肾小球滤过率估算值(eGFR)在糖尿病肾病中的临床价值.方法 应用受试者工作特征曲线分析血清TFF3 联合UREA、Cr、Cys-C 及eGFR在糖尿病肾病中诊断中的作用.血清TFF3采用酶联免疫吸附试验,UREA、Cr、C...

Diagnosis value of trefoil factor 3 combined with urea,creatinine,cystatin C and estimated glomerular filtration rate in diabetic nephropathy

Objective To discuss the clinical value of serum trilobular factor 3( TFF3) combined with urea,creatinine( Cr),cystatin C( Cys-C) and estimated glomerular filtration rate( e GFR) in diabetic nephropathy. Methods The diagnostic role of serum TFF3 combined with urea,Cr,Cys-C and e GFR in diabetic nephropathy was evaluated by using receiver operating characteristic( ROC) curve. Serum levels of TFF3 was determined by enzyme-linked immunosorbent assay( ELISA),and urea,Cr,Cys-C and e GFR were detected by automatic biochemical analyzer. Results ROC curve analysis revealed that the sensitivity and specificity of TFF3,urea,Cr,Cys-C,e GFR and the combined predictive values were 83. 87%,63. 44%,34. 41%,40. 86%,51. 61%,82. 80% and 95. 35%,95. 35%,97. 67%,90. 70%,100. 00% and 100. 00% in diabetic nephropathy,respectively. Area under curve( AUC) of the combined predictive value was significantly higher than single indicator( P < 0. 01). AUC of TFF3 was significantly higher than Cys-C,urea and e GFR,with the differences statistically significant( P < 0. 01). The sensitivity and specificity of TFF3,urea,e GFR and the combined predictive value were 74. 14%,58. 62%,39. 66%,75. 86% and 95. 35%,95. 35%,97. 67% and 100. 00% in early diabetic nephropathy,respectively.Logistic regression analysis showed that serum TFF3 and UREA were predictive risk factors for diabetic nephropathy or early diabetic nephropathy( P < 0. 05). Conclusion Serum TFF3 is a new potential biomarker for the diagnosis of diabetic nephropathy or early diabetic nephropathy. Combination with other renal function assessment indicators showed more diagnostic efficacy and worth for clinical application.