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Mediators and receptors in the resolution of inflammation: drug targeting opportunities |
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| Authors: | AG Stewart |
| Affiliation: | Department of Pharmacology, The University of Melbourne, Melbourne, Vic., Australia |
| Abstract: | The active resolution of inflammation is recognized as offering new opportunities to generate novel anti-inflammatory agents. The emerging appreciation of the importance of active resolution in regulation of inflammation also creates an imperative to examine developing and existing agents for their potential to influence these pathways. This themed issue of the British Journal of Pharmacology contains papers that discuss the roles of annexin-1, lipoxins and related lipid products of fish oils as well as other mechanisms involved in active resolution and their receptor targets.This article is part of a themed issue on Mediators and Receptors in the Resolution of Inflammation. To view this issue visit http://www3.interscience.wiley.com/journal/121548564/issueyear?year=2009 |
| Keywords: | annexin-1 formyl peptide receptor lipoxin A4 protectins resolvins protease anti-protease balance protease-activated receptor fish oil eicosapentaenoic acid docosahexaenoic acid |