碱性磷酸酶与白蛋白比值对急性冠脉综合征患者介入治疗预后的影响

目的 评估碱性磷酸酶(ALP)与白蛋白(ALB)比值(APAR)对急性冠脉综合征(ACS)患者预后的影响.方法 按前瞻队列研究连续入选2015年1月至2016年12月就诊于中国医科大学附属盛京医院确诊为ACS并择期进行经皮冠状动脉支架植入术(PCI)治疗的患者共2162例.根据入院次日APAR分成两组,收集所有患者临床...

Effect of alkaline phosphatase-to-albumin ratio in predicting prognosis of patient with acute coronary syndrome after percutaneous coronary intervention.

Objective To determine the effect of alkaline phosphatase-to-albumin ratio(APAR)on the prognosis of patients with acute coronary syndrome(ACS). Methods By prospective cohort study,a total of 2162 patients with ACS diagnosed in Shengjing Hospital of China Medical University from January 2015 to December 2016 were enrolled for the study. All patients underwent selective percutaneous coronary artery intervention. Then the patients were divided into two groups according to the APAR on the day after admission;collect all patients’ clinical data,the severity of coronary lesion,postoperative medication,and record the clinical endpoint events at 1 year follow-up. The effect of APAR on the prognosis was studied by the COX regression analysis. Results COX analysis shows that APAR values were associated with allcause mortality[HR(95%CI)2.432(1.475,4.010),P<0.001]and cardiogenic mortality[HR(95%CI)2.884(1.627,5.111),P<0.001]. Multivariate analysis adjusted for variables shows it was also associated with them[HR(95%CI)1.839(1.059,3.192),P=0.03],[HR(95%CI)2.232(1.170,4.258),P=0.01]. APAR is more stronger predictor of prognosis than ALP,ALB(area under curve:0.635,0.592,0.397). Conclusions Patients with high APAR had higher long-term all-cause mortality and cardiac mortality,so APAR can be considered as a predictor of prognosis on patients with ACS.