复方多黏菌素B软膏联合中药坐浴对老年肛周脓肿术后病人伤口愈合效果及血清表皮生长因子表达的影响

目的探讨复方多黏菌素B软膏联合中药坐浴对老年肛周脓肿术后病人伤口愈合效果及血清表皮生长因子(EGF)表达的影响。方法选取我院肛肠外科78例老年肛周脓肿拟行手术治疗的病人,采用单盲随机数表法将其分为试验组(40例)和对照组(38例)。2组病人术后第1天开始均采用医院自制中药包坐浴,15~20 min/次,2次/d。试验组病人于坐浴后擦干患处,涂抹复方多黏菌素B软膏。治疗7 d后,观察2组伤口愈合情况,采用VAS、生活质量量表(SF-36)、匹兹堡睡眠质量指数(PSQI)量表评价2组病人的生活质量,采用ELISA法检测2组病人的血清EGF水平。结果治疗7 d后,试验组的伤口痊愈者较对照组显著增多(P<0.05),伤口水肿者较对照组显著减少(P<0.05);2组肛瘘和伤口渗血发生率差异无统计学意义(P>0.05);试验组的VAS、PSQI评分较治疗前和对照组显著下降(P<0.01),SF-36评分及EGF水平较治疗前和对照组显著升高(P<0.01)。试验组和对照组病人在第10天伤口愈合的比例分别为40%和26%,2组比较,差异有统计学意义(P<0.05)。结论复方多黏菌素B软膏联合中药坐浴对老年肛周脓肿术后病人的伤口愈合具有较好的临床疗效,其起效快,可以缓解疼痛、改善生活质量和睡眠状况,并且通过上调病人的血清EGF水平促进伤口愈合。

Effects of compound polymyxin B ointment combined with traditional Chinese medicine sitz bath on wound healing and serum epidermal growth factor expression in elderly patients with perianal abscess after operation

Objective To investigate the effects of compound polymyxin B ointment combined with traditional Chinese medicine sitz bath on wound healing and serum epidermal growth factor(EGF)expression in the elderly patients with perianal abscess after operation.Methods A total of 78 elderly patients with perianal abscess in our hospital were selected.The patients were randomly divided into the experimental group(n=40)and the control group(n=38)using single-blind random number table.All the patients took the hospital-made traditional Chinese medicine package sitz bath on the first day after surgery,15-20 min/time,twice per day.After sitz bath,the patients in the experimental group were given compound polymyxin B ointment applications additionally.After 7 days of treatment,the wound healing of the two groups was observed.The quality of life was evaluated by pain visual analogue scores(VAS),life quality scale(SF-36)and Pittsburgh Sleep Quality Index(PSQI),and the level of serum EGF was detected by enzyme linked immunosorbent assay(ELISA).Results After 7 days of treatment,the wound healing rate of the experimental group was significantly higher than that of the control group(P<0.05),and the wound edema rate was significantly reduced(P<0.05);There was no significant difference in the incidence of anal fistula and wound bleeding(P>0.05);The scores of VAS and PSQI in the experimental group were significantly lower(P<0.01),and the SF-36 score and EGF level were significantly higher than those before treatment and those in the control group(P<0.01).The wound healing rate of the experimental group and the control group was 40%and 26%respectively on the 10th day(P<0.05).Conclusions Compound polymyxin B ointment combined with traditional Chinese medicine sitz bath has a good clinical effect on wound healing in the elderly patients with perianal abscess after surgery.It can relieve pain,improve quality of life and sleep status,and promote wound healing by increasing serum EGF level.