姜黄素固体分散体处方工艺优化及体外溶出度评价

目的 优化姜黄素固体分散体(CUR SD)的处方工艺.方法 根据溶解度参数及溶出结果 ,优选CUR SD最佳载体及药物与载体的比例.采用差示扫描量热(DSC)法、X-射线粉末衍射分析(XRPD)法和傅立叶红外光谱分析(FTIR)法对制备的CUR SD进行表征,并考察体外溶出度.结果 根据溶解度参数及体外溶出结果 ,优选...

Formulation and Technology Optimization and in Vitro Dissolution Evaluation of Curcumin Solid Dispersion

Objective To optimize the formulation of Curcumin Solid Dispersion(CUR SD).Methods Based on solubility parameters and dissolution results,the best carrier of CUR SD and the ratio of drugs to carrier were optimized.CUR SD was characterized by Differential Scanning Calorimetry(DSC),X-ray Powder Diffraction(XRPD)and Fourier Transform Infrared(FTIR)spectroscopy,and its dissolution was evaluated.Results PVP K30 was selected as the best carrier by solubility parameters and dissolution results.Furthermore,the mass ratio of drug and carrier was optimized to 1∶3 and 1∶1.5 to prepare CUR SD.The results of DSC and XRPD showed that CUR and piperine(PIP)were highly dispersed in the carrier in an amorphous state.FTIR spectroscopy indicated that there was intermolecular hydrogen bond interaction between the drugs and the carrier.The results of dissolution in vitro showed that the cumulative dissolution rate and dissolution rate of CUR SD were significantly increased.Conclusion By optimizing the formulation process,the prepared CUR SD can effectively improve the dissolution of CUR and PIP in vitro.