老年人血小板参数与血压水平的相关性研究

目的探讨老年人群血小板参数与其血压水平的相关性。方法收集2016年1月至2019年8月于同济大学附属天佑医院门诊及体检的1023例老年人的临床资料。根据血压水平将其分为3组正常血压组(<120/80 mmHg,215例)、高血压前期组[(120~139/80~89)mmHg,531例]、高血压组(≥140/90 mmHg,277例),分析血小板参数与血压的相关性。结果高血压组和高血压前期组的血小板平均体积(MPV)和血小板分布宽度(PDW)均高于正常血压组(P<0.05),而各组间PLT和血小板压积(PCT)的差异均无统计学意义(P>0.05)。Spearman相关分析显示,MPV和PDW与SBP均呈显著正相关(P<0.01),而PLT和PCT均与SBP无相关性(P>0.05),MPV、PDW、PLT和PCT均与DBP无相关性(P>0.05)。多元线性回归分析显示,MPV是SBP的独立影响因素(β=0.110,P<0.01)。按照MPV四分位法将研究对象由低到高分为Q1~Q4组,多元Logistic回归分析显示,在校正性别、年龄、身高、体质量、BMI、腰围、臀围、腰臀比、TC、TG、LDL-C、血肌酐、ALT、FPG、吸烟、饮酒因素后,Q4组发生高血压的危险性是Q1组的1.529倍(95%CI1.106~2.319,P<0.05)。结论老年人群血小板参数与其血压水平密切相关,其中MPV升高可能与高血压的发生及发展有关。

Correlation between platelet parameters and blood pressure in the elderly

Objective To analyze the correlation between platelet parameters and blood pressure in the elderly.Methods The clinical data of 1023 elderly patients in Tianyou Hospital Affiliated to Tongji University from January 2016 to August 2019 were collected.According to the level of blood pressure,they were divided into three groups normotension group(<120/80 mmHg,n=215),prehypertension group[(120-139)/(80-89)mmHg,n=531]and hypertension group(≥140/90 mmHg,n=277).The correlation between platelet parameters and blood pressure was analyzed.Results The levels of mean platelet volume(MPV)and platelet distribution width(PDW)in hypertension group and prehypertension group were higher than those in normotension group(P<0.05),but platelet count(PLT)and platelet thrombocytocrit(PCT)showed no significant difference among the three groups.Spearman correlation analysis showed that MPV and PDW were positively correlated with systolic blood pressure(SBP)(P<0.01);PLT and PCT were not correlated with SBP(P>0.05);MPV,PDW,PLT and PCT were not correlated with diastolic blood pressure(DBP)(P>0.05).The multiple linear regression analysis showed that MPV was an independent factor of SBP(P<0.01).All the elderly were divided into Q1-Q4 groups according MPV quartile division.Logistic regression analysis showed that the risk of hypertension in Q4 group was 1.529 times of that in Q1 group(95%CI1.106-2.319,P<0.05)after adjusting for gender,age,height,body weight,body mass index,waist circumference,hip circumference,waist-to-hip ratio,total cholesterol,triglyceride,low-density lipoprotein cholesterol,creatinine,alanine aminotransferase,fasting blood glucose,smoking and drinking.Conclusions Platelet parameters are closely related to blood pressure in the elderly,elevated MPV may be associated with the occurrence and development of hypertension.