复方丹参液静滴对腰椎间盘突出症患者自由基代谢的影响

目的　观察复方丹参注射液静滴对腰椎间盘突出症 (LIDP)患者血清一氧化氮 (NO)和超氧化物歧化酶 (SOD)的影响及其疗效。方法　将 62例LIDP患者随机分为丹参组 31例和常规组 31例进行比较 ,于治疗前、后分别用硝酸还原酶法和羟胺氧化法测定患者血清NO含量及SOD活性 ,同时应用目测类比评分法 (VAS)对疼痛进行评估 ,采用LIDP疗效定量评价表进行疗效评定。结果　LIDP患者经复方丹参液静滴治疗后 ,血浆NO含量减少和SOD活性增高与常规组相比 ,差异有显著性 (P <0 .0 5) ;丹参组疗效优于常规组。结论　复方丹参注射液静滴可降低LIDP患者NO水平 ,提高SOD活性 ,增强机体抗氧化能力 ,减轻自由基的损害 ,临床疗效优于常规组

Effects of intravenous drip of Compound Dan Shen Injection on plasma NO and SOD levels in patients with lumbar intervertebral disc prolapse

Objective To observe the effects of intravenous drip of Compound Dan Shen Injection on plasma nitric oxide (NO) and superoxide dismutase (SOD) levels in patients with lumbar intervertebral disc prolapse (LIDP) and the therapeutic effect. Methods Sixty two cases of LIDP were randomly divided into Compound Dan Shen Injection intravenous drip treatment group (Dan Shen group) ( n =31) and routine treatment group (routine group) ( n =31). The level of plasma NO and SOD were measured before treatment and 2 weeks after treatment .The assessment including pain grading using visual analogue scale (VAS) and therapeutic effects evaluation using LIDP quantitative evaluation scale at the same time. Results The SOD of the patients in the two groups increased after treatment and the level of NO decreased ( P <0.05). As compared with the routine group, the levels of plasma NO decreased significantly in the Compound Dan Shen Injection group and the activities of SOD significantly higher ( P < 0.05 ) than routine group. The effect of Compound Dan Shen Injection group is better than that of routine group in the treatment of LIDP. Conclusion Compound Dan Shen Injection can decrease the level of NO and increased the level of SOD of the patients with LIDP and increased the antioxidization capacity to alleviate the damage by oxygen free radicals, and yield better therapeutic result than of routine intervention for patients with LIDP.