| 抗肿瘤药物的治疗监测 |
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| 引用本文： | 钱新华,张能芳,高凌. 抗肿瘤药物的治疗监测[J]. 药学与临床研究, 2003, 11(6): 36-39 |
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| 作者姓名： | 钱新华 张能芳 高凌 |
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| 作者单位： | 江苏省肿瘤防治研究所,南京,210009 |
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| 摘 要： | 大多数抗肿瘤药具有治疗指数低、毒性大、药动学参数个体差异大的特性 ,临床需进行治疗药物监测 ,以达到个体化给药。但治疗药物监测最基本的条件———量效关系 ,对大多数肿瘤药而言只是量毒关系 ,基于提高临床疗效的治疗药物监测除少数药物外目前尚不可行
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| 关 键 词： | 抗肿瘤药 治疗药物监测 个体化给药 |
| 文章编号： | 1007-306(2003)06-36-04 |
| 修稿时间： | 2003-04-23 |
Therapeutic Drug Monitor for Anticancer Drug |
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| Qian xinhua,Zhang nengfang,Gao ling Jiangsu Cancer Research Institute. Therapeutic Drug Monitor for Anticancer Drug[J]. Pharmacertical and Clinical Research, 2003, 11(6): 36-39 |
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| Authors: | Qian xinhua Zhang nengfang Gao ling Jiangsu Cancer Research Institute |
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| Affiliation: | Nanjing 210009 |
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| Abstract: | Most anticancer drugs have the feature of l ow ther apeutic index,high toxicity and wide inter-patient variability of pharmacokine ti c parameters,therapeutic drug monitor (TDM) is needed in individual chemothera p y of cancer. But the basic element,dose-efficacy relationship. For TDM of ant ic ancer drug is dose-toxicity relationship only,therefore TDM for improving cli nical efficacy is not practicable except for few anticancer drug. |
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| Keywords: | Anticancer drug TDM Individual chemotherapy |
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