大鼠实验性心肌梗塞时血浆蛋白C,纤溶活性变化及人参皂甙作用的研究

通过观察实验性大鼠急性心肌梗塞（ＡＭＩ）时血浆蛋白Ｃ（ＰＣ）活性和组织型纤溶酶原激活剂（ｔ－ＰＡ）及纤溶酶原激活剂的特异性抑制因子（ＰＡＩ）活性的变化，初步探讨了心肌缺血时ＰＣ活性变化与纤溶系统的关系以及人参皂甙对其变化的影响。结果表明，１．ＡＭＩ时血浆ＰＣ活性显著低于正常对照组，且与缺血程度呈负相关。２．ＡＭＩ时ｔ－ＰＡ活性降低，ＰＡＩ活性增高。３．人参皂甙可提高ＡＭＩ时血浆ＰＣ活性，降低ＰＡＩ

THE CHANGES OF PLASMA PROTEIN C ACTIVITY, FIBRINOLYSIS FUNCTION IN ACUTE MYOCARDIAL INFARCTION AND EFFECT OF PANAX SAPONIN

In present study,the changes of plasma PC activity and fibrinolysis activity were investigated in rat with acute myocardial infarction. The effect of panax saponin on PC and fibrinolysis activity was also observied in this animal model- The results indicated that-1. plasma PC activity in acute myocardial infarction was significantly lower than that in normal control (P<0. 01). 2. tissue-type plasmino-gen activator (t-PA) activity was obviously decreased. On the contrary, plasminogen activator inhibitor (PAD activity was significantly increased. 3. Administration with panax saponim,both PC and t-PA activity were higher than that of group the without panax saponim,but the PAI activity was evidently lower than that of without drug group. These data suggested that the decrease of PC activity in acute myocardial infarction was associated with abnormality of fibrinplysis function. Panax saponin may be effective in this pathologic state.