Beta lactoglobulin homologue placental protein 14 (PP14) in serum of patients with trophoblastic disease and non-trophoblastic gynecologic malignancy |
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Authors: | G N Than G Tatra D G Szabó I F Csaba H Bohn |
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Institution: | (1) Department of Obstetrics and Gynecology and Institute of Biochemistry, University Medical School, Édesanyák u. 17, H-7624 Pécs, Hungary;(2) Second Department of Obstetrics and Gynecology, University of Vienna, Medical School, Vienna, Austria;(3) Research Laboratories, Behringwerke AG, Marburg/Lahn, FRG |
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Abstract: | Summary Serum levels of beta lactoglobulin homologue placental protein 14 (PP14) were measured by a sensitive radioimmunoassay in various trophoblastic diseases and non-trophoblastic gynecologic malignancies. While trace amounts of protein were detected in sera of non-pregnant subjects (22.3±13.7 g/l), during first half of normal pregnancy a dramatic rise of serum-PP14 levels was demonstrable with a peak-value at 7th–10th week of gestation, followed by a decline thereafter. Serial determinations of PP14 have been performed in 31 patients with trophoblastic tumour (20 hydatidiform moles, 4 invasive moles and 7 choriocarcinomas). In patients with hydatidiform moles and invasive moles (273.5±106.5 g/l and 162.2±109.6 g/l) respective values before therapy were much exceeding the nonpregnant controls. After therapy there was a rapid decline of the serum-PP14 levels within two weeks. In patients with choriocarcinoma the PP14 values were moderately elevated (66.4±25.7 g/l), and declined following the remission of disease. In 32 gynecological tumours (21 carcinomas of the cervix, 4 endometrial carcinomas, 5 ovarian carcinomas, 2 carcinomas of the vulva) the pretreatment levels were not different to normal controls. |
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Keywords: | Beta lactoglobulin homologue-PP14 Radioimmunoassay of PP14 Trophoblastic diseases Non-trophoblastic gynecological tumors |
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