不同血液病病人骨髓CFU-F的变化

本文主要利用体外细胞液体培养技术,对几种血液病病人骨髓CFU-F增殖能力及其对GM-CFU刺激作用等几方面进行检测。结果表明,MDS和巨幼红细胞型贫血病人骨髓CFU-F集落明显高于正常对照(P<0.01),且MDS病人骨髓CFU-F的变化与病情严重程度有密切关系;ALL病人骨髓CFU-F、GM-CFU集落数都明显低于正常对照(P<0.01),处于缓解状态的白血病病人CFU-F集落数明显高于未缓解者(P<0.01)。我们认为,并不是所有的血液病病人都有骨髓微环境的变化,但往往微环境的变化出现在严重及预后不佳者。

Changes in bone marrow CFU-F in patients with different blood diseases

The proliferative ability of CFU-F and stimulation of CFU-F on GM-CFU in liquid culture in vitro in ALL, MDS, etc.were examined.It was shown that the number of CFU-F colonies in patients with MDS and megaloblastic anemia increased more obviously,while changes in bone marrow CFU-F in patients with MDS varied with the severity of the disease,being decreased in the critical stage in comparison to that in the remission stage. In ALL patients, the numbers of CFU-F and GM-CFU colonies were obviously lower than those in the control groups. Leukemic patients in the remission stage had CFU-F colony numbers obviously higher than those not in the remission stages. It is suggested that changes in the microenvironment do not take place in all leukemic patients, but only in serious hemopoietic disorders and patients with worse drognoses.