新诊断的2型糖尿病患者胰岛素泵治疗前后血糖的动态变化

目的观察新诊断的2型糖尿病（T2DM）患者胰岛素泵治疗前后血糖漂移变化特征，评估胰岛素泵强化控制血糖的疗效。方法选取新诊断的T2DM患者38例，随机分为胰岛素泵治疗组（csⅡ）18例，胰岛素多次皮下注射组（MSⅡ）20例，对其治疗前后采用动态血糖监测系统（CGMS）进行连续3d的血糖监测，进行自身前后对照和组间对照分析。结果两组患者经2周治疗后糖代谢紊乱明显缓解，38例治疗前后全天平均血糖（MBG）、日内血糖平均波动幅度（MAGE）、日伺血糖平均绝对差（MODD）比较差异均有统计学意义（P〈0．001）；治疗后血糖〉7．8mmol／L和〉11．1mmol／L所占13内时间百分比与治疗前比较均有显著降低（P〈0．001）；治疗后餐前及餐后各时段的平均血糖水平亦显著下降（P〈0．05，P〈0．01）。上述各项血糖参数csⅡ组均优于MSⅡ组（P〈0．01，P〈0．001）。结论动态血糖监测能评估血糖漂移变化特征，胰岛素泵为强化控制血糖的有效方法。．

Dynamic changes of glycemic excursions before and after treatment by continuous subcutaneous insulin infusion in new diagnosed patients with type 2 diabetes mellitus

Objective To observe the characteristics of glycemic excursion and to evaluate the therapeutic effects on blood glucose in new dignosed type 2 diabetes mellitus after being given continuous subcutaneous insulin infusion(CS Ⅱ).Methods Thirty-eight new dignosed type 2 diabetes mellitus patients were randomly divided into group CS Ⅱ(n=18) and group many-times subcutaneous insulin infusion(MS Ⅱ,n=20).The blood glucose lasted for three days were monitored by continuous glucose monitoring system(CGMS).Results The abnormal glucose metabolism in two groups were markedly released after two weeks treatment,the mean blood glycemic(MBG),mean amphtude of glycemic excursions(MAGE),means of daily differences(MODD) and the percentage of blood glucose beyond 7.8 mmol/L and 11.1 mmol/L after therapy were all significantly decreased compared with those of before therapy (P＜0.001);the average levels of blood glucose before and after diet were decreased obviously as well(P＜0.05,P＜0.01).All index in group CS Ⅱ were lower than that of group MS Ⅱ (P＜0.01,P＜0.001).Conclusion Continuous glucose monitoring system can assess the changes characteristics of blood glucose effectively,continuous subcutaneous insulin infusion was an effective means of controlling blood glucose.