阵发性室上性心动过速发作时及终止后血浆内皮素及心钠素浓度变化

应用放射免疫方法测定了３０例阵发性室上性心动过速（ＳＶＴ）发作时及终止后血浆内皮素（ＥＴ）、心钠素（ＡＮＰ）浓度，并与４２例正常人比较。结果表明：ＳＶＴ发作时及终止后３０分钟的血浆ＥＴ、ＡＮＰ浓度二者均有非常显著差异（Ｐ＜０．０１），在ＳＶＴ发作时血浆ＥＴ、ＡＮＰ均显著升高，在终止后３０分钟就明显降低，但仍分别高于正常对照组１倍。由于ＡＮＰ和ＥＴ在生物学上具有相互拮抗作用，在ＳＶＴ发作时及终止后ＥＴ和ＡＮＰ呈平行的升高和降低，说明了两种激素参与了ＳＶＴ的病理生理过程，这种现象可能是机体自稳态调节功能之一。

Changes of plasma endothelin and atrial natriuretic peptide during onset and after termination of paroxysmal supraventricular tachycardia

Radioimmunoassay was used to measure the changes in plasma endothelin (ET) and atrial natriuretic peptide (ANP) during the onset and after termination of paroxysmal supraventricular tachycardia(SVT).30 cases were reviewed and comparisons with 42 normal subjects were made.There were very significant changes( P <0 0001)in both plasma ET and ANP during the onset and 30 minutes after the termination of SVT.During the onset of SVT,the plasma ET and ANP were markedly elevated and 30 minutes after its termination they were lowered significantly,but their concentrations were still two fold higher than those of th control group.As the biological effects of ANP and ET are antalonistic to each other,their parallel elevation and lowering of plasma concentrations during and after the termination of SVT reveal that these two hormones participate in the pathophysiological process of SVT.This phenomenon is possibly one of the homeostatic regulatory functions in the organism.