我国钢铁厂噪声与高血压发病风险关系的Meta分析

目的 探讨钢铁厂工人噪声暴露与高血压发病风险的关系。方法 使用计算机联机检索国内外数据库，通过关键词收集相关研究文献，提取数据后使用Stata 12.0软件进行Meta分析。结果 共检索到3 392篇相关文献，经筛选后纳入12篇文献，涉及我国6个地区。使用随机效应模型对各组效应量进行合并，钢铁厂暴露噪声组高血压的发病风险是未暴露组的2.09倍（OR=2.09，95%CI：1.68~2.60）。其中当噪声暴露量为<85 dB（A）时合并OR为1.24（95%CI：0.60~2.54），85~dB（A）时合并OR为1.74（95%CI：1.27~2.37），95~dB（A）时合并OR为3.38（95%CI：2.61~4.37），≥ 105 dB（A）时合并OR为5.51（95%CI：3.84~7.90）。剂量-反应关系结果表明当钢铁厂噪声增加时，高血压发病风险随之增加。经敏感性分析及发表偏倚检验，Meta分析结果稳定。结论 钢铁厂噪声可能使我国职业工人血压升高，且患高血压的危险性随噪声暴露等级增高而逐渐增加。

Association between steel plant noise and hypertension in China: a Meta-analysis

Objective To evaluate the relationship between noise exposure and the risk of hypertension in steel plant of China.Methods Based on the online search for publication,related literatures were collected according to keywords from home and abroad,Stata 12.0 was used to perform Meta-analysis.Results The total identified papers were 3 392 from databases,12 included articles involving 6 regions of China met the eligibility criteria.A random effects model was used to calculate the OR with 95％ confidence intervals (CI) for the effect size.Noise exposure was positively associated with prevalence of hypertension(OR =2.09,95％ CI:1.68-2.60),the OR for ＜ 85 dB (A) group was 1.24 (95％ CI:0.60-2.54),85-dB(A) group was 1.74 (95％ CI:1.27-2.37),95-dB(A) group was 3.38 (95％ CI:2.61-4.37),and ≥105 dB(A) group was 5.51 (95％ CI:3.84-7.90).Besides,hypertension risk would increase along with the increasing of noise exposure.The results were stable judged by sensitivity analysis and published bias analysis.Conclusions Noise in the steel plant may increase the risk of hypertension and it may go rising as the noise exposure becoming more severe.