代谢综合征患者综合干预效果研究

目的 探索以合理膳食、加强体育锻炼、戒烟限酒为核心的综合干预措施对于代谢综合征（metabolic syndrome，MS）患者的干预效果及可行性。方法 根据国际糖尿病联盟诊断标准，以被诊断为MS的机关事业单位人员作为研究对象，进行12个月的干预。对照组患者每2个月接受1次MS相关防治知识讲座。在对照组的基础上，应用自我管理的方法对干预组患者开展以合理膳食、加强体育锻炼、戒烟限酒为核心的综合干预。于干预前、干预6个月及干预12个月后对研究对象进行体格检查和生化指标检测。通过问卷调查比较干预前后患者相关知识的知晓率变化情况。结果 干预12个月后干预组患者相关知识的知晓率高于对照组。干预组患者体重指数、腰围、收缩压、舒张压、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、空腹血糖水平下降幅度及高密度脂蛋白胆固醇水平上升幅度均大于对照组（均有P<0.05）。结论 以合理膳食、增加体育运动、戒烟限酒为主要内容的综合干预对MS患者是一种有效的干预措施。

The effect of comprehensive interventions for metabolic syndrome patients

Objective To explore the effect and feasibility of comprehensive interventions majoring in healthy diet,physical activity,smoking cessation and appropriate alcohol use for patients with metabolic syndrome (MS).Methods Patients who work in the government organizations and institutions diagnosed with MS according to the International Diabetes Federation Criteria were included in the study and given intervention for 12 months.All patients received relevant health courses every 2 months.Intervention group patients received additional comprehensive interventions including healthy diet,physical activity,smoking cessation and appropriate alcohol use with self-management method.Physical examination and biochemical indicators testing were performed before,6 months and 12 months after the intervention respectively.Questionnaire investigations on MS related knowledge were implemented before and after the intervention.Results MS related knowledge awareness rate was higher in intervention group than control group after 12 month intervention.Intervention group patients' body mass index,waist circumference,systolic blood pressure,diastolic blood pressure,triglyceride,total cholesterol,low-density lipoprotein cholesterol,fasting plasma glucose levels and high-density lipoprotein cholesterol level were significantly different with control group (all P ＜ 0.05).Conclusions Comprehensive intervention measures majoring in healthy diet,physical activity,smoking cessation and appropriate alcohol use are effective for MS patients.