生命早期饥荒暴露对成年期代谢综合征患病风险的影响

目的 探索生命早期饥荒暴露对成年后代谢综合征患病风险的影响。方法 采用中国健康与养老追踪调查2011年全国基线数据，共2854名研究对象纳入分析。将出生于1956-1958年、1959-1961年和1962-1964年的研究对象分为饥荒前出生组、饥荒期出生组以及非暴露组（对照组）。以中华医学会糖尿病学分会2004年相关标准诊断代谢综合征。联合应用双重差分模型和疾病风险评分匹配方法控制偏倚和混杂。结果 饥荒前出生组、饥荒期出生组、非暴露组代谢综合征患病率分别为16.00%、16.47%和14.86%，无论是否进行疾病风险评分匹配，模型中双重差分项均不显著（均有P>0.05），饥荒暴露组与非暴露组相比，代谢综合征患病风险无显著差异。结论 本研究结果提供的证据不足以充分证实生命早期饥荒暴露会增加成年后代谢综合征患病风险，有待大样本人群研究对该问题作进一步探索。

Effect of famine exposure in the early life on risk of metabolic syndrome in adulthood

Objective To examine whether exposure to the Chinese famine during fetal life or early childhood is associated with the risk of metabolic syndrome(MS) in adulthood.Methods A data of 2 854 adults born between 1956 and 1964 from the 2011 Chinese Health and Retirement Longitudinal Survey (CHARLS) was used.Three groups were defined as pre-famine(born in 1956-1958),famine exposure(born in 1959-1961) and non-exposed group(post-famine,born in 1962-1964).The Chinese Diabetes Society(CDS) criteria were used for the definition of metabolic syndrome.Difference in difference model(DID) and disease risk score(DRS) matching approach based on conditional logistic regression were utilized to adjust the effects of age and other potential confounders.Results The prevalence of MS were 16.00％,16.47％ and 14.86％ among participants of pre-famine,famine and post-famine groups respectively.But after adjusting covariates by DRS matching,the interactions in the DID models were not significant(all P ＞ 0.05),meaning the odds ratio (OR) was not significantly bigger than one and that the two famine exposed groups of participants didn't have a significantly higher risk of developing metabolic syndrome.Conclusions There is no significant evidence in our study to support that famine exposure in early life will increase the risk of MS in adulthood.Further studies with larger sample size are needed to confirm the hypothesis.