2001-2013年金昌队列人群冠心病死亡趋势及疾病负担研究

目的 了解金昌队列人群冠心病（coronary heart disease，CHD）的死亡趋势，以及冠心病对该人群造成的疾病负担。方法 利用建立的大型随访队列人群的资料，应用死亡率、潜在减寿年数（potential years of life lost，PYLL）、潜在工作损失年数（working years of potential life lost，WYPLL）等指标，分析2001-2013年该队列人群的冠心病死亡趋势和疾病负担现状，运用平均增长速度描述疾病负担的变化趋势。结果 2001-2013年金昌队列人群冠心病粗死亡率为40.47/10万，其中男性标化死亡率随年份有增长趋势，但是70~79岁组冠心病的死亡率随年份呈下降趋势。女性因冠心病造成的人均潜在减寿年数（average potential years of life lost，APYLL）（15.33年/人）是男性（6.95年/人）的2.21倍。人均潜在工作损失年（average working years of potential life lost，AWYPLL）女性（5.59年/人）是男性（3.42年/人）的1.63倍，其中人均潜在工作损失年和男性人均潜在寿命损失年随年份呈下降趋势。结论 2001-2013年金昌队列人群的冠心病死亡率有上升趋势，并对该人群造成沉重的疾病负担，应该对该人群展开进一步的冠心病防治措施。

The trend of coronary heart disease mortality and disease burden in Jinchang cohort from 2001 to 2013

Objective To explore the trend of coronary heart disease (CHD) mortality and disease burden in Jinchang Cohort. Methods The data were collected from a large follow-up cohort. The main indicators, including mortality, potential years of life lost (PYLL), and working years of potential life lost (WYPLL), were used to evaluate the trend of coronary heart disease mortality and the disease burden during the period from 2001 to 2013 in this cohort, the average growth rate was used to describe the trend of disease burden. Results The crude mortality rate of CHD during the period from 2001 to 2013 in Jinchang cohort was 40.47 per 100 000, the standardized mortality rate of CHD for male increased, but the coronary heart disease mortality of 70-79 years old group decreased. During the thirteen years, the average potential years of life lost (APYLL) of CHD for female (15.33 years per person) was 2.21 times than male (6.95 years per person), the average working years of potential life lost (AWYPLL) of CHD for female (5.59 years per person) was 1.63 times than male (3.42 years per person), while the average working years of potential life lost (AWPYLL) and the average potential life lost (APYLL) for male decreased. Conclusions The mortality rate of CHD on the rise from 2001 to 2013 in Jinchang cohort and it caused heavy burden. We should take further measures to prevent CHD.