广东顺德地区原发性肝癌发病危险因素研究

目的 探讨广东顺德地区原发性肝癌发病的危险因素，为预防肝癌发生提供科学依据。方法 采用频数匹配的病例-对照研究，在757例原发性肝癌病例及1 061例对照中，应用t检验、χ²检验和非条件Logistic回归模型分析资料。结果 病例组与对照组的年龄和性别分布差异均无统计学意义（均有P>0.05）。多因素分析显示，与肝癌发病风险有统计学关联的因素包括乙型肝炎病毒（hepatitis B virus，HBV）慢性感染（OR=25.82，95%CI：18.11~36.83，P<0.001）、恶性肿瘤家族史（OR=2.58，95%CI：1.72~3.88，P<0.001）、吸烟（OR=2.92，95%CI：2.01~4.26，P<0.001）、饮酒（OR=1.93，95%CI：1.34~2.79，P<0.001）、饮用江河沟塘水（OR=3.82，95%CI：2.72~5.35，P<0.001）、食用鱼生类食物（OR=2.47，95%CI：1.47~4.12，P=0.001）、食用腌制食物（OR=2.57，95%CI：1.86~3.55，P<0.001）、喝茶（OR=0.21，95%CI：0.14~0.30，P<0.001）、职业在岗（OR=0.34，95%CI：0.23~0.50，P<0.001）。结论 HBV慢性感染、有恶性肿瘤家族史、吸烟、饮酒、饮用江河沟塘水、食用鱼生类食物和食用腌制食物是肝癌的危险因素，喝茶和职业在岗可能是肝癌的保护因素。

Analysis of the risk factors for primary liver cancer in Shunde region,Guangdong

Objective To explore the risk factors of primary liver cancer in Shunde,Guangdong,and to provide scientific basis for prevention of liver cancer.Methods A frequency-matched case-control study was conducted,including 757 liver cancer cases and 1 061 controls.The non-conditional Logistic regression model was applied to explore the potential risk factors.Results There were no significant differences in distribution of sex and age between cases and controls (P ＞0.05).As shown by the multivariate Logistic regression analysis,the factors associated with the risk of liver cancer included chronic hepatitis B virus (HBV) infection (OR =25.82,95％ CI:18.11-36.83,P ＜ 0.001),family history of cancer (OR =2.58,95％ CI:1.72-3.88,P ＜ 0.001),smoking (OR =2.92,95 ％ CI:2.01-4.26,P ＜ 0.001),alcohol drinking (OR =1.93,95％ CI:1.34-2.79,P ＜ 0.001),drinking river water or ditch pond water (OR =3.82,95％ CI:2.72-5.35,P ＜ 0.001),eating raw fish (OR =2.47,95 ％ CI:1.47-4.12,P =0.001),eating pickled food (OR =2.57,95％ CI:1.86-3.55,P ＜0.001),tea drinking (OR =0.21,95％ CI:0.14-0.30,P ＜0.001) and in-service status (OR =0.34,95％ CI:0.23-0.50,P ＜0.001).Conclusions Chronic HBV infection,family history of cancer,smoking,alcohol drinking,drinking river water or ditch-pond water,eating raw fish and eating pickled food are the risk factors for primary liver cancer,while tea drinking and in-service status may be protective factors.