Surgical management of retroperitoneal sarcomas associated with external and intraoperative electron beam radiotherapy. |
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| Authors: | J Y Bobin T Al-Lawati L E Granero M Adham P Romestaing O Chapet S Issac J P Gerard |
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| Institution: | Department of Surgical Oncology, Centre Hospitalier Lyon Sud, 69495 Pierre Benite Cedex, France. service.bobin@chu-lyon.fr |
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| Abstract: | AIMS: To report outcomes of adults with retroperitoneal sarcoma (RS) treated by surgery, external beam radiotherapy (EBRT) and intraoperative electron beam radiotherapy (IORT). METHODS: From July 1988 to February 2001; 24 patients with primary and recurrent RS were diagnosed and treated. The median dose and energy of IORT delivered was 15 Gy/9meV. EBRT dose varies between 45-50 Gy. RESULTS: There were five primary and 19 recurrent tumours. One primary and five recurrent tumours underwent R0 resection. There were 12 liposarcomas and 19 grade I tumours; 13 patients developed local recurrence and three developed distant metastases.Twenty-two patients received IORT associated with EBRT: 11 developed recurrences. Six patients developed Neurotoxicity (4 grade II and 2 grade III). Disease free survival and overall survival at 5 years was 28 and 56% respectively. CONCLUSIONS: EBRT with IORT treatment is a promising technique for local control. Lower recurrence rates are associated with radical (R0) surgical procedures. |
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