Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum |
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| Authors: | N-Y Yang S-H Qian J-A Duan P Li L-J Tian |
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| Institution: |
a Department of Pharmacognosy, China Pharmaceutical University, Nanjing, China
b Department of Phytochemistry, Jiangsu Academy of Traditional Chinese Medicine, Nanjing, China
c Technology Center, Jinling Pharmaceutical Company Limited, Nanjing, China |
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| Abstract: | Three new germacrane sesquiterpenes, eupalinolides C-E (1-3), along with three known germacrane sesquiterpenes, eupalinolide A (4), eupalinolide B (5), and 3β-acetoxy-8β-(4'-hydroxytigloyloxy)-14-hydroxycostunolide (6), were isolated from Eupatorium lindleyanum. They were tested for cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. The results showed that these compounds demonstrated potent cytotoxicity. The structures of the compounds were elucidated by means of 1H and 13C NMR spectroscopic analysis, including 2D NMR experiments. |
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| Keywords: | Eupatorium lindleyanum Compositae Sesquiterpene Eupalinolide C Eupalinolide D Eupalinolide E |
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