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A randomized study comparing timolol and methyldopa in hospital treatment of puerperal hypertension
Authors:JACK FTDLER  VALERIE SMITH  MICHAEL DE  SWIET
Affiliation:Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, Goldhawk Road, London W6 OXG, and University College London, School of Medicine, Department of Clinical Pharmacology, Faculty of Clinical Science, University Street, London WC1E 6JJ
Abstract:Summary. Treatment of puerperal hypertension (diastolic blood pressure 95–105 mm Hg) with methyldopa 750–3000 mg/day was compared with treatment with timolol 15–60 mg/day in a random trial of 80 patients. Within these dose ranges and over the period studied (9 days) both drugs appeared equally effective. Therefore, in the treatment of puerperal hypertension, timolol could be considered as a suitable alternative to methyldopa.
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