Impact of plasmin and its complexes with α2-macroglobulin or α2-antiplasmin on the proliferative activity of human lymphocyteson the proliferative activity of human lymphocytes |
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| Authors: | M I Musatov S G Zhabin V I Konenkov N A Zorin |
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| Institution: | (1) Central Research Laboratory, State Institute for Postgraduate Medical Studies, Novokuznetsk;(2) Laboratory of Clinical Immunogenetics, Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | It is shown that plasmin in doses of 0.1, 1, or 10 μg/ml did not influence significantly phytohemagglutinin-induced proliferation
of mononuclear lymphocytes in a 3-day culture with these cells. Their proliferative response to pokeweed mitogen was stimulated
by plasmin in the dose of 10 μg/ml only. Biogenic complexes of plasmin with α2-macroglobulin or α2-antiplasmin induced a moderate reduction of spontaneous proliferation after 3 days of culture, and so did plasmin after 5
days; α2-macroglobulin induced a dose-dependent comitogenic effect with phytohemagglutinin and pokeweed mitogen, while α2-antiplasmin induced a dose-independent comitogenic effect with pokeweed mitogen.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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9, pp. 304–305, September, 1994
Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences |
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| Keywords: | plasmin α 2-macroglobulin α 2-antiplasmin lymphocytes proliferation |
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