| 苦参素对HSC-T6整合素αv表达的影响 |
| |
| 引用本文： | 张汝建,王天才,杨明峰,王海霞,王君林. 苦参素对HSC-T6整合素αv表达的影响[J]. 胃肠病学和肝病学杂志, 2008, 17(9): 737-737,740 |
| |
| 作者姓名： | 张汝建 王天才 杨明峰 王海霞 王君林 |
| |
| 作者单位： | [1]华中科技大学同济医学院同济医院消化科,湖北武汉430030 [2]山东省泰山医学院,湖北武汉430030 |
| |
| 摘 要： | 为探讨持参素对活化的肝星状细胞整合素αv表达和失巢凋亡的影响，把培养激活的HSC—T6分为对照组及实验组，实验组以不同浓度的昔参素干预（分刖为30、60、120、240、480、960mg／L），Westernblot检测整合素αv的表达，结果发现药物千预后整合素αv的表达逐渐降低（分别降低18．4％、30.5％、39．8％、52％、62．3％、76．5％，P〈0．05），且呈浓度依赖性（r=-0．76），表明苦参素能通过抑制整合素αv的表达来影响肝纤维化的发展。
|
| 关 键 词： | 整合素 肝犟状细胞 苦参素 失巢凋广 |
Effect of Kwoninone on the integrin av expressing of HSC-T6 |
| |
| ZHANG Rujian,WANG Tiancai,YANG Mingfeng,WANG Haixia,WANG Junlin. Effect of Kwoninone on the integrin av expressing of HSC-T6[J]. Chinese Journal of Gastroenterology and Hepatology, 2008, 17(9): 737-737,740 |
| |
| Authors: | ZHANG Rujian WANG Tiancai YANG Mingfeng WANG Haixia WANG Junlin |
| |
| Affiliation: | ZHANG Rujian, WANG Tiancai, YANG Mingfeng, WANG Haixia, WANG Junlin( 1. Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030; 2. Taishan Medical College, Shandong Province, China) |
| |
| Abstract: | To explore the effect of Kwoninone on the expression of integrin αv and anoikis in HSC-T6. HSC-T6 cells were treated with Kwoninone in different concentration（30, 60, 120, 240, 480 and 960 rag/L, respectively） or without treatment as enntrnl. The expression of integrin αv in various groups were detected by Western blot. The expression of integrin αv in Kwoninone treated cells significantly decreased. The decrease was in dose-dependent manner comparing with the control group（ P 〈 0.05）. Kwoninone can suppress the expression of integrin α. |
| |
| Keywords: | Integrin Hepatic stellate cell Kwoninone Anoikis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
