| 晚期血吸虫病患者肝脏内γ干扰素的免疫组织化学研究 |
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| 引用本文： | 李祖进,刘绍春,杨青,杨业翔,曾令兰,李淑莉,罗端德,戴家珠,王心禾.晚期血吸虫病患者肝脏内γ干扰素的免疫组织化学研究[J].华中科技大学学报(医学版),1992(6). |
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| 作者姓名： | 李祖进 刘绍春 杨青 杨业翔 曾令兰 李淑莉 罗端德 戴家珠 王心禾 |
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| 作者单位： | 同济医科大学附属协和医院传染病学教研室
(李祖进，杨青，曾令兰，李淑莉，罗端德，戴家珠)，同济医科大学病理学教研室
(刘绍春)，湖北省江陵县血吸虫病防治站
(杨业翔)，同济医科大学附属协和医院传染病学教研室(王心禾) |
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| 摘 要： | 采用间接免疫荧光技术检测了22例晚期血吸虫病患者肝脏内γ干扰素(IFN-γ)的分布。发现晚期血吸虫病患者肝内IFN-γ主要分布于汇管区虫卵肉芽肿内、肉芽肿外层和虫卵周围。大量纤维结缔组织增生的汇管区基本无或有很少量的IFN-γ存在.提示IFN-γ可能在血吸虫病的肝脏免疫病理中起重要作用。
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| 关 键 词： | 日本血吸虫病 肝脏 γ干扰素 |
An Immunohistochemical Study of Interferon-y in the Liver of Patients with Advanced Schistosomiasis Japonica |
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| Li Zujin,Liu Shaochun,Yang Qing,Yang Yiexiang,Zheng Linglan,Li Shuli,Luo Duande,Dai Jiazhu,Wang Xinhe.An Immunohistochemical Study of Interferon-y in the Liver of Patients with Advanced Schistosomiasis Japonica[J].Journal of Huazhong University of Science and Technology(Health Sciences),1992(6). |
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| Authors: | Li Zujin Liu Shaochun Yang Qing Yang Yiexiang Zheng Linglan Li Shuli Luo Duande Dai Jiazhu Wang Xinhe |
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| Institution: | Li Zujin,Liu Shaochun,Yang Qing,Yang Yiexiang,Zheng Linglan,Li Shuli,Luo Duande,Dai Jiazhu,Wang XinheDepartment of Infectious Diseases,Xiehe Hospital,Tongji Medical University,Wuhan^Department of Pathology,Tong/i Medical University**Jiangling Station of Antischistosomiasis,Jiangling County,Hubei Province |
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| Abstract: | The distribution of interferon-Y(INF-Y) in the liver of 22 patients with advanced schistosomiasis japonica was detected with indirect immunofluo-rescence method using monoclonal antibody. It was found that INF-Y was mainly located in egg granulomas, around eggs in the portal area of the liver of patients with advanced schistosomiasis, and in the outlayer of granuloma. The INF-Y around eggs was dispersively distributed. Little or no INF-Y was deposited in some portal areas in which a large amount of fibrotic tissue was proliferated. The results indicate that INF-Y may play an important role in the liver immunopathology of patients with schistosomiasis japonica. |
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