| 双氟甲基鸟氨酸抑制大鼠脑缺血后迟发性神经元死亡的研究 |
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| 引用本文： | 胡应安,张茂先.双氟甲基鸟氨酸抑制大鼠脑缺血后迟发性神经元死亡的研究[J].首都医学院学报,1996,17(4):255-258. |
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| 作者姓名： | 胡应安 张茂先 |
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| 作者单位： | 首都医科大学生理学教研组 |
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| 摘 要： | 观察阻断脑血流１０ｍｉｎ后腹腔注射双氟甲基鸟氨酸（ＤＦＭＯ）大鼠海马ＣＡ１区域迟发性神经元死亡（ＤＮＤ）现象的变化。结果显示：ＤＦＭＯ对大鼠海马ＣＡ１区神经元有明显的保护作用，并且在一定范围内与ＤＦＭＯ的剂量有正相关关系。ＤＦＭＯ的上述作用只有在脑缺血后及时给药才能出现。实验还提示：多胺及其代谢限速酶鸟氨酸脱羧酶（ＯＤＣ）在ＤＮＤ的产生中具有一定作用。
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| 关 键 词： | 脑缺血，细胞存活，海马，鸟氨酸脱羧酶 |
| 收稿时间： | 1995-12-25 |
Difluoromethyl Ornithine Reduced Delayed Neuronal Death in the Rat Hippocampus Following Transient Brain Ischemia |
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| Hu Ying''an, Zhang Maoxian.Difluoromethyl Ornithine Reduced Delayed Neuronal Death in the Rat Hippocampus Following Transient Brain Ischemia[J].Journal of Capital University of Medical Sciences,1996,17(4):255-258. |
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| Authors: | Hu Ying'an Zhang Maoxian |
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| Institution: | Department of Physiology, Capital University of Medical Sciences |
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| Abstract: | Delayed neuronal death occured in the rat hippocampus following brief ischemia. We study and evaluate the effects of difluoromethyl ornithine (DFMO). ODC inhibitor, on the survival of neurons in the hippocampal CA_1 subfield. The pyramidal cell density in the CA_1 region is used as index of the effects. The results of experiment showed that DFMO has considerably reduced neuron loss in the CA_1 region. The favorabal effects are obviously dose-dependent and administration time-dependent. Furthermore, the results suggest that polyamine and ODC might play an importent role in the genesis of the delayed neuronal death following transient cerebral ischemia. |
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| Keywords: | cerebral ischemia cell survival hippocampus ornithine decarboxylase |
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