首发精神分裂症患者脑电超慢涨落图分析

目的探讨脑电超慢涨落图（ET）与阴性、阳性精神分裂症异质性的关系。方法对首次发作未用药精神分裂症患者50例进行阳性阴性临床症状量表（PANSS）评定和脑电超慢涨落图检测。结果阴性、阳性精神分裂症组与正常对照组相比，NE、5-HT活动显著降低，DA活动显著升高，差异具有统计学意义。阴性、阳性精神分裂症组两组比较，GABA和Glu、AchR、DA活动明显异常，差异具有统计学意义。PANSS总分与Ach、DA有相关性，阳性量表分与GABA、Ach、AchR、DA有相关性，阴性量表分与Glu、5-HT、DA有相关性，精神病理分与AchR、DA有相关性。结论阳性症状可能与GABA、Ach、AchR、DA具有相关性，阴性症状可能与Glu、5-HT、DA具有相关性。ET检测可作为诊断精神分裂症的依据之一。

Change of neurotransmitters in schizophrenia with ET analysis

Objective:To research the change of neurotransmitters in schizophrenia with Encephalofluctuograph technology(ET).Methods:The Encephalofluctuograph technology was recorded and the positive and negative syndrome scale(PANSS)were rated in 50 patients with schizophrenia.Results:As compared to normal controls,the neurotransmitter level of NE,5-HT declined and that of DA increased;There were significant difference in GABA,Glu,AchR,DA between positive subtype and negative subtype of schizophrenia.PANSS total score correlated with Ach and DA.Positive score correlated with GABA,Ach,AchR,DA.Negative score correlated with Glu,5-HT and DA.The general psychopathological score correlated with AchR and DA.Conclusion:ET may provide a diagnostic evidence for schizophrenia.