| 同型半胱氨酸促血管平滑肌细胞增殖的机制 |
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| 引用本文： | 关丽,贾光宏,邵菊芳. 同型半胱氨酸促血管平滑肌细胞增殖的机制[J]. 中国心血管杂志, 2002, 7(3): 161-162 |
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| 作者姓名： | 关丽 贾光宏 邵菊芳 |
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| 作者单位： | 1. 深圳市罗湖区人民医院 518001
2. 华中科技大学同济医学院附属同济医院,武汉,430030 |
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| 摘 要： | 目的 研究同型半胱氨酸 (HCY)对血管平滑肌细胞 (VSMC)细胞周期、细胞周期素和 P2 7蛋白表达的影响。方法 用流式细胞技术测定细胞周期、细胞周期素和 P2 7蛋白表达量。结果 HCY促进 VSMC增殖和细胞 S期合成 ,同时使细胞周期素 D、E、A表达明显增加 ,P2 7蛋白表达下降。结论 HCY促进 VSMC增殖和细胞 S期合成可能是通过增加细胞周期素 D、E、A的表达 ,抑制 VSMC中 P2 7蛋白的表达来实现的。
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| 关 键 词： | 同型半胱氨酸 平滑肌细胞 增殖 |
| 修稿时间： | 2001-12-07 |
The mechanisms of homocysteine increasing vascular smooth muscle cells proliferating |
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| Guan li,Jia Guanghong,Shao Jufang. The mechanisms of homocysteine increasing vascular smooth muscle cells proliferating[J]. Chinese Journal of Cardiovascular Medicine, 2002, 7(3): 161-162 |
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| Authors: | Guan li Jia Guanghong Shao Jufang |
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| Abstract: | Objective To study the effects of homocysteine(HCY) on cell cycle, cyclins and P27 expressions in cultured vascular smooth muscle cells(VSMC). Methods Cell cycle distribution, cyclins and P27 expression were determined by flow cytometer. Results HCY elevated the proliferation of VSMC and cells synthesizing in S phase.It also increased cyclins D,E,A expressions and inhibited P27 expression in VSMC. Conclustion It may be that promotion of VSMC growth and cell synthesizing in S phase by HCY are achieved through increasing cyclins D, E, A expressions and inhibiting P27 expression. |
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| Keywords: | Homocyteine Smooth muscle cell Proliferation |
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