老年性黄斑变性的多焦视网膜电图改变

目的 测试并比较正常人和老年性黄斑变性患者的多焦视网膜电图。方法 应用美国EDI公司生产的VERIS science 4.0 视诱发反应图象系统对17例20只正常眼、7例10只老年性黄斑变性(age-related macular degeneration,AMD）干性型眼，8例　8只AMD湿性型眼和11例11只特发性黄斑裂孔(idiopathic macular hole,IMH)眼进行检测。将各组老年性黄斑变性者6个环形视网膜区域的N₁、P ₁波潜伏期和平均反应密度值与正常对照组进行比较。 结果 AMD湿性型各环N₁、P ₁ 波潜伏期和AMD干性型3～6环处N₁波潜伏期明显长于正常人。AMD湿性型在1～4环处N₁波和1～6环处P ₁波平均反应密度值下降，AMD干性型在1～5环处N₁波和1～6环处P ₁波平均反应密度值下降，IMH者在1～2环处N₁、1～3环处P ₁波平均反应密度值低于正常人。 结论 多焦视网膜电图可对老年视网膜穿孔黄斑变性部位进行视功能的定量检测。(中华眼底病杂志,2000,16:224-226)

The multifocal electroretinography in age-related macular degeneration

PurposeTo measure and compare the difference of multifocal electroretinogram in normal subjects and patients with age-related macular degeneration.MethodsSeventeen cases(20 eyes)of normal subjects,7 cases(10 eyes)of dry form AMD(age-related macular degeneration),8 cases(8 eyes)of wet-form AMD and 11 cases(11 eyes)of idiopathic macular hole(IMH)were tested with VERIS Sciences^TM 4.0 made by EDI company of America.The latencies and average response densities of 6 ring retinal regions in normal subjects were compared with those in various types of age-related maculopathies.ResultsThe N₁ and P₁ wave latencies of all 6 rings in wet-form AMD and the N₁ wave latencies of 3～6 rings in dry-form AMD were delayed statistically.The N₁ and P₁ wave average response densities of 1～4 rings in and the P₁ wave average response densities of 1-6 rings wet-form AMD and the N ₁ wave average response densities of 1～5 and the P₁ wave average response densties of 1-6 rings in dry-form AMD were decreased statistically.The N₁ and P₁ wave average response densities of 1～2 and the P₁ wave average esponse densities of 1～3 rings were decrease statistically in IMH.ConclusionMultifocal electroretinogram can be used to quantitate the visual function of the affected location in age-related macular degeneration.(Chin J Ocul Fundus Dis,2000,16:224-226)