冠状动脉旁路移植术后静脉桥再狭窄的影响因素

作为治疗冠状动脉粥样硬化性心脏病的常规方法,冠状动脉旁路移植术广泛应用于临床。自体大隐静脉是移植血管的主要来源,但移植术后再狭窄不仅降低了手术成功率并且严重影响了患者的生存时间。移植损伤、血管扩张、管壁缺血、血流动力学改变等因素引起多种细胞因子和生长因子分泌,促使血管平滑肌细胞增生并向内膜迁移,进而引起细胞外基质沉积、斑块形成,最终导致移植静脉再狭窄。人为干预再狭窄的方法有药物、血管外支架、扩张液、电磁辐射和基因工程等,但单一因素的干预往往不能取得令人满意的效果,因此多因素联合干预将成为研究发展的主要方向。

Influencing Factor on Restenosis of Vein Graft After Coronary Artery Bypass Grafts

As a conventional approach,the coronary artery bypass grafting(CABG)is widely used in treatment of coronary artery heart disease(CAD).The autologous great saphenous vein is main source of graft,but the problem of restenosis post-operation has greatly influenced the effect of CABG and live span of the patient.Many factors including operational injure,hemangiectasis,ischemia and hemodynamics change cause the increasing secretion of cytokine and nutrilit,which result to vascular smooth muscle cell(VSMC)hyperpl...