| Kiss-1、E-cadherin在胎盘部位滋养细胞肿瘤中的表达及相关性 |
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| 引用本文： | 辛礼辉,练玲芝,惠京. Kiss-1、E-cadherin在胎盘部位滋养细胞肿瘤中的表达及相关性[J]. 中国妇幼保健, 2011, 26(33): 5240-5242 |
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| 作者姓名： | 辛礼辉 练玲芝 惠京 |
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| 作者单位： | 天津医科大学病理学教研室,天津,300070 |
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| 摘 要： | 目的:探讨肿瘤抑制蛋白Kiss-1和黏附分子E-cadherin在胎盘部位滋养细胞肿瘤中的表达及相关性。方法:采用免疫组化PowerVision二步法检测20例正常早孕绒毛、15例葡萄胎、15例绒癌、10例胎盘部位滋养细胞肿瘤(PSTT)中Kiss-1和E-cadherin的表达情况及相关性。结果:Kiss-1、E-cadherin在正常早孕绒毛、葡萄胎、PSTT、绒癌中表达呈下降趋势,差异有统计学意义(P<0.05)。Kiss-1、E-cadherin在正常早孕绒毛和葡萄胎的表达差异无统计学意义(P>0.05);在PSTT中表达低于正常早孕绒毛和葡萄胎中表达,差异有统计学意义(P<0.05);PSTT和绒癌的表达差异无统计学意义(P>0.05)。Kiss-1和E-cadherin在正常早孕绒毛、葡萄胎、PSTT、绒癌中表达呈正相关(r=0.627,P<0.05)。结论:Kiss-1和E-cadherin低表达或表达缺失可能在PSTT的浸润和转移过程中发挥重要作用,二者具有协同作用。
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| 关 键 词： | 胎盘部位滋养细胞肿瘤 免疫组织化学 Kiss-1 E-cadherin |
Expressions of Kiss-1 and E-cadherin in placental trophoblastic tumor and their correlation |
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| XIN Li-Hui,LIAN Ling-Zhi,HUI Jing. Expressions of Kiss-1 and E-cadherin in placental trophoblastic tumor and their correlation[J]. Maternal and Child Health Care of China, 2011, 26(33): 5240-5242 |
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| Authors: | XIN Li-Hui LIAN Ling-Zhi HUI Jing |
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| Affiliation: | XIN Li-Hui,LIAN Ling-Zhi,HUI Jing.Department of Pathology,Tianjin Medical University,Tianjin 300070,China |
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| Abstract: | Objective:To explore the expressions of tumor suppressor protein(Kiss-1) and adhesion factor(E-cadherin) in placental trophoblastic tumor and their correlation.Methods:Immunohistochemical PowerVision method was used to detect the expression levels of Kiss-1 and E-cadherin in 20 specimens of chorionic villi of normal pregnancy,15 specimens of hydatidiform mole,15 specimens of chorioepithelioma and 10 specimens of placental trophoblastic tumor and their correlation.Results:The expression levels of Kiss-1 and ... |
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| Keywords: | Placental trophoblastic tumor Immunohistochemistry Kiss-1 E-cadherin |
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